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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
14.55
Human Site:
S227
Identified Species:
22.86
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S227
E
E
D
N
E
I
E
S
E
E
E
V
Q
P
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S227
E
E
D
N
E
I
E
S
E
E
E
V
Q
P
K
Dog
Lupus familis
XP_531814
1283
145094
E210
G
V
G
D
S
D
S
E
G
L
D
S
P
V
K
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
S227
E
E
D
N
Y
N
E
S
E
E
E
A
Q
P
S
Rat
Rattus norvegicus
XP_002726765
1361
151628
S230
E
E
E
N
Q
D
E
S
E
E
E
T
Q
P
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
H331
E
M
E
Q
F
V
S
H
E
E
D
V
K
G
N
Frog
Xenopus laevis
NP_001089247
1340
149481
K210
A
S
H
D
E
E
V
K
T
K
T
P
S
R
E
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
S229
V
K
E
K
T
K
P
S
R
R
P
P
R
A
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
G132
S
D
D
S
V
S
S
G
A
E
E
V
S
P
S
Honey Bee
Apis mellifera
XP_392346
1120
127429
K62
N
K
N
L
E
D
R
K
R
I
Y
K
D
D
E
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
S128
S
P
E
S
T
P
Q
S
T
P
K
R
G
G
K
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
R209
T
I
R
R
R
K
P
R
A
A
A
K
N
A
M
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
D217
K
D
V
S
E
E
E
D
V
D
L
M
D
E
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
N210
D
D
D
V
E
M
G
N
V
E
E
D
K
S
D
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
D184
K
N
D
G
D
E
D
D
D
I
A
D
D
K
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
6.6
N.A.
73.3
66.6
N.A.
N.A.
26.6
6.6
6.6
N.A.
33.3
6.6
13.3
0
P-Site Similarity:
100
N.A.
100
20
N.A.
73.3
80
N.A.
N.A.
53.3
26.6
26.6
N.A.
46.6
26.6
40
0
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
13.3
N.A.
N.A.
26.6
6.6
N.A.
P-Site Similarity:
53.3
N.A.
N.A.
60
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
0
14
7
14
7
0
14
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
20
40
14
7
20
7
14
7
7
14
14
20
7
7
% D
% Glu:
34
27
27
0
40
20
34
7
34
47
40
0
0
7
27
% E
% Phe:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
7
7
0
0
7
7
7
0
0
0
7
14
0
% G
% His:
0
0
7
0
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
0
14
0
0
0
14
0
0
0
0
0
% I
% Lys:
14
14
0
7
0
14
0
14
0
7
7
14
14
7
27
% K
% Leu:
0
0
0
7
0
0
0
0
0
7
7
0
0
0
0
% L
% Met:
0
7
0
0
0
7
0
0
0
0
0
7
0
0
7
% M
% Asn:
7
7
7
27
0
7
0
7
0
0
0
0
7
0
14
% N
% Pro:
0
7
0
0
0
7
14
0
0
7
7
14
7
34
0
% P
% Gln:
0
0
0
7
7
0
7
0
0
0
0
0
27
0
0
% Q
% Arg:
0
0
7
7
7
0
7
7
14
7
0
7
7
7
0
% R
% Ser:
14
7
0
20
7
7
20
40
0
0
0
7
14
7
14
% S
% Thr:
7
0
0
0
14
0
0
0
14
0
7
7
0
0
0
% T
% Val:
7
7
7
7
7
7
7
0
14
0
0
27
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
7
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _